|
KMID : 1022820120030010020
|
|
Journal of Multiple Sclerosis and Neuroimmunology
2012 Volume.3 No. 1 p.20 ~ p.25
|
|
|
Prognosis of Patients with Acute Myelitis; A Single Hospital-based Rdtrospective Analysis
|
|
Kim Ji-Sun
Jang Jae-Hong
|
|
|
Abstract
|
|
|
|
Acute myelitis (AM) may be the initial presentation of multiple sclerosis (MS) or neuromyelitisoptica (NMO). Therefore, predicting conversion risk to MS or NMO is one of many key considerations in the management of patients with AM. To identify the clinical and laboratory variables in patients with first-ever AM that predict relapses or conversion to NMO or MS. We selected patients who met the following criteria; (1) patients who were visited to our hospital for myelitis as first-ever inflammatory disorders in central nervous system from May 2006 to April 2011, (2) at least 24 months follow-up after onset of symptoms. We reviewed medical records to recruit data related to demographics, clinical features, and ancillary tests. The prognostic values of all variables were analyzed for conversion to MS or NMO. Of 31 patients with AM, 5 patients (mean age 32.6 years) converted to MS (3 women) or NMO (2 women), and 26 (18 men and 8 women, mean age 45.0 years) remained monophasic. Mean follow-up time was 6.1 years. Female gender (p = 0.008) and dissemination in space on MRI by MAGNIMS criteria (p = 0.029) were associated with conversion to MS or NMO.There were no significant differences in age of onset, clinical characteristics, CSF findings, spinal MRI or evoked potentials between two subgroups. Brain lesions and being female with AM may be risk factors in the development of MS or NMO.
|
|
|
KEYWORD
|
|
|
Acute myelitis, Multiple sclerosis, Neuromyelitis optica
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|